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Immune deficiencies

Immune deficiency (or immune deficiency) is a state in which the immune system's ability to fight infections is compromised.  If one is getting recurrent infections without a specific reason, then one would evaluate the immune system.

IgA deficiency

Selective immunoglobulin A deficiency (SIgAD) is a primary immunodeficiency disease and is the most common of the primary antibody deficiencies, and affects 1 in 400 to 600 people. It
 is 
not usually 
associated
 with 
bacterial
infections
 but
 may 
be 
associated with 
autoimmune or
allergic 
diseases.
The 
genetic 
causes 
of 
sIgAD
 are
 unclear.
People
 affected
 have very 
low 
or 
absent 
levels 
of 
one
 type 
of 
antibody, 
called
 immunoglobulin 
A, 
but produce
protective
 antibodies 
of 
the 
other 
types 
of 
immunoglobulin
 (IgG
 and
 IgM).


Antibody Deficiency

Common variable immune deficiency (CVID) is the name for a group of conditions that affect how the body’s immune system makes antibodies and fights infections. People with CVID have either low levels of immunoglobulin in their blood or none at all; they are unable to make functional antibodies of the IgG or IgA types, though some patients do make IgM antibodies. This means those affected can’t fight infection against mainly bacteria, but also viruses, parasites and fungi, as well as people with a fully working immune system. Patients may have severe, persistent or repeated infections, often from the same germ. These infections often particularly affect the ears, sinuses, chest, lungs or gut – places that come into daily contact with infectious agents.

Other problems with Immune system

There are many other immune deficiencies, which can make one more susceptible to get infections. Autoimmune conditions are when the Immune system starts to fight against ones-own-self. Several conditions are thought to be secondary to problems with immune system but they are not. The key to diagnosing a problem with immune system is by taking a detailed clinical history. Further testing of immune system is based on a good history. 

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